Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.

BACKGROUND Heart development is tightly regulated by signaling events acting on a defined number of progenitor and differentiated cardiac cells. Although loss of function of these signaling pathways leads to congenital malformation, the consequences of cardiac progenitor cell or embryonic cardiomyocyte loss are less clear. In this study, we tested the hypothesis that embryonic mouse hearts exhi...

The Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss Running title :

A weighted metric method to optimize multi-response robust problems

In a robust parameter design (RPD) problem, the experimenter is interested to determine the values of con-trol factors such that responses will be robust or insensitive to variability of the noise factors. Response sur-face methodology (RSM) is one of the effective methods that can be employed for this purpose. Since quality of products or processes is usually evaluated through several quality ...

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response to persistent transcription-blocking DNA damage, although the relevant lesions have not been identified. Here we show that loss of NTH-1, the only Base Excision Repair (BER) ...

[Computerized cardiotocography analysis of fetal heart response to acoustic stimulation].

PURPOSE to study the effect of acoustic stimulation in the fetal cardiac response, according to parameters from computerized cardiotocography in low risk pregnancies. METHODS twenty low risk pregnant women were included in the study, according to the following criteria: age over 18; single gestation, living fetus; gestational age between 36 and 40 weeks; amniotic liquid index over 8.0 cm and ...